| 摘要 |
<p>A method of producing an adhesive patch, comprising a supporting body layer and an adhesive layer disposed on at least one surface of the supporting body layer, includes: a process A of obtaining an adhesive layer composite containing a mixture of one species selected from the group consisting of an oxybutynin and a pharmacologically acceptable salt thereof, one species selected from the group consisting of an acrylic polymer and a rubber-based polymer, a liquid paraffin, an organic acid, and a tackifier; a process B of heating the adhesive layer composite for 2-24 hours at a temperature in the range of (melting point°C) to (melting point +10°C) of the drug; a process C of obtaining the adhesive body layer containing the drug in a state of supersaturated concentration and soluble form by cooling the adhesive layer composite at a cooling rate of 1 to 20°C/hour after the above heating. [Reference numerals] (AA) First run; (BB) Second run; (CC) Temperature</p> |
