发明名称 |
Methods for treating hypercholesterolemia |
摘要 |
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides. |
申请公布号 |
US8664190(B2) |
申请公布日期 |
2014.03.04 |
申请号 |
US201113302070 |
申请日期 |
2011.11.22 |
申请人 |
FREIER SUSAN M.;CROOKE ROSANNE M.;GRAHAM MARK J.;LEMONIDIS KRISTINA L.;BHANOT SANJAY;TRIBBLE DIANE;WATT ANDREW T.;ISIS PHARMACEUTICALS, INC. |
发明人 |
FREIER SUSAN M.;CROOKE ROSANNE M.;GRAHAM MARK J.;LEMONIDIS KRISTINA L.;BHANOT SANJAY;TRIBBLE DIANE;WATT ANDREW T. |
分类号 |
C12N15/11;A61K48/00;C07H21/02;C07H21/04 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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