| 摘要 |
594310 Disclosed is a conjugate comprising: a ligand for a glutathione transporter; wherein the ligand is selected from the group consisting of: glutathione, S-(p-bromobenzyl)glutathione, gamma-(L-gamma-azaglutamyl)-S-(p-bromobenzyl)-L-cysteinylglycin, S-butylglutathione, S-decylglutathione, glutathione reduced ethyl ester, glutathionesulfonic acid, S-hexylglutathione, S-lactoylglutathione, S-methylglutathione, S-(4-nitrobenzyl)glutathione, S-octylglutathione, S-propylglutathione, n-butanoyl gamma-glutamylcysteinylglycine, ethanoyl gamma-glutamylcysteinylglycine, hexanoyl gammaglutamylcysteinylglycine, octanoyl gamma-glutamylcysteinylglycine, dodecanoyl gamma-glutamylcysteinylglycine, GSH monoisopropyl ester (N-(N-L-glutamyl-L-cysteinyl)glycine 1-isopropyl ester sulfate monohydrate) and glutathione derivatives of the formula I and a pharmaceutically acceptable nanocontainer encapsulating an anthracycline, wherein the nanocontainer is a nanocontainer selected from the group consisting of: A. a carrier protein; B. a liposome; C. a polyplex system; D. a lipoplex system; and, E. polyethyleneglycol; wherein the ligand in a) is conjugated to at least one of the anthracycline and the nanocontainer in b). |
