发明名称 |
Insulin-like growth factor II (IGF-II) binding factors |
摘要 |
This invention relates to modified IGF-II binding domains of the Insulin-like Growth Factor 2 Receptor (IGF2R) which have enhanced binding affinity for IGF-II relative to the wild type IGF-II binding domain. Suitable IGF-II binding domains may be modified, for example, by substituting residue E1544 for a non-acidic residue. These modified domains may be useful in the sequestration of Insulin-like Growth Factor II (IGF-II), for example, in the treatment of cancer. |
申请公布号 |
US8658423(B2) |
申请公布日期 |
2014.02.25 |
申请号 |
US201213618064 |
申请日期 |
2012.09.14 |
申请人 |
HASSAN ANDREW BASSIM;ZACCHEO OLIVER;PRINCE STUART;CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
HASSAN ANDREW BASSIM;ZACCHEO OLIVER;PRINCE STUART |
分类号 |
C12N5/00;C07K14/575;C07K14/61;C07K14/71;C12N15/63 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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