| 发明名称 |
Humanized anti-TNFalpha antibodies |
| 摘要 |
The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved. |
| 申请公布号 |
US8658171(B2) |
申请公布日期 |
2014.02.25 |
| 申请号 |
US201213405144 |
申请日期 |
2012.02.24 |
| 申请人 |
ZHU BAOGUO;TAO DESHENG;SUN BILL NAI-CHAU;SUN LEE-HWEI KING;LIOU RUEY SHYAN;SUN CECILY ROU-YUN;LI QIANG;PENG YUCAI;ZHANG JINGWEI;HU ZHENXIANG;LIVZON MABPHARM INC. |
发明人 |
ZHU BAOGUO;TAO DESHENG;SUN BILL NAI-CHAU;SUN LEE-HWEI KING;LIOU RUEY SHYAN;SUN CECILY ROU-YUN;LI QIANG;PENG YUCAI;ZHANG JINGWEI;HU ZHENXIANG |
| 分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
