Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus

摘要

Compounds having the general formula (I): are provided which have enhanced inhibitory potency and are thus useful in methods of prophylaxis or treatment of a viral infection such as hepatitis C virus. The compounds are phosphoramidate derivatives of nucleoside compounds derived from bases such as adenine and guanine. The glycoside moiety of the nucleoside compound can be substituted at the ss-2' position with methyl and the phosphoramidate group can be 1-naphthyl linked by -O- to the P atom. These compounds can be administered as pharmaceutical compositions, and methods for their preparation are also provided.