发明名称 |
Recombinant melusin fusion protein as pharmacological agent in the treatment of heart pathologies |
摘要 |
A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i) a human melusin protein having the amino acid sequence as defined in SEQ ID No.:1, or a homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity to SEQ ID No.:1 and having the function of native melusin protein or a human melusin portion derived from SEQ ID No.:1 or homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity of the melusin portion derived from SEQ ID No.:1 and having the function of native melusin protein and ii) a cell penetrating polypeptide. |
申请公布号 |
US8658598(B2) |
申请公布日期 |
2014.02.25 |
申请号 |
US201113106251 |
申请日期 |
2011.05.12 |
申请人 |
ACCORNERO FEDERICA;BRANCACCIO MARA;TARONE GUIDO;LEMBO GIUSEPPE;CARNEVALE DANIELA;TARGET HEART BIOTEC S.R.L. |
发明人 |
ACCORNERO FEDERICA;BRANCACCIO MARA;TARONE GUIDO;LEMBO GIUSEPPE;CARNEVALE DANIELA |
分类号 |
A61P9/04;A61K38/16;C07H21/02;C07K19/00;C12P21/02 |
主分类号 |
A61P9/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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