发明名称 |
Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
摘要 |
Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b5-like domain and at least one mutation within the HDASH (SEQ ID NO:8) motif are disclosed. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases, along with a method of making long chain polyunsaturated fatty acids ["PUFAs"], are also disclosed. |
申请公布号 |
US8658413(B2) |
申请公布日期 |
2014.02.25 |
申请号 |
US201113218673 |
申请日期 |
2011.08.26 |
申请人 |
BOSAK MELISSA D.;BOSTICK MICHAEL W.;HE HONGXIAN;HONG SEUNG-PYO;POLLAK DANA M. WALTERS;SHARPE PAMELA L.;WANG YEHONG JAMIE;XUE ZHIXIONG;YADAV NARENDRA S.;ZHANG HONGXIANG;ZHU QUINN QUN;E I DU PONT DE NEMOURS AND COMPANY |
发明人 |
BOSAK MELISSA D.;BOSTICK MICHAEL W.;HE HONGXIAN;HONG SEUNG-PYO;POLLAK DANA M. WALTERS;SHARPE PAMELA L.;WANG YEHONG JAMIE;XUE ZHIXIONG;YADAV NARENDRA S.;ZHANG HONGXIANG;ZHU QUINN QUN |
分类号 |
C12N1/20;C07H21/04;C12N9/00 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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