RAPID AFFINITY MEASUREMENT OF PEPTIDE LIGANDS AND REAGENTS THEREFOR
摘要
The present invention provides methods for rapidly screening and measuring the ligand binding affinity of in vitro selected peptides to the cognate and off-target proteins. This general strategy is amenable to high throughput analysis because the peptides are synthesized by cell-free translation, as opposed to solid-phase synthesis required by traditional assays, and affinities can be readily measured in standard formats.
申请公布号
WO2013185042(A3)
申请公布日期
2014.02.20
申请号
WO2013US44731
申请日期
2013.06.07
申请人
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THESTATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY;CHAPUT, JOHN;LARSEN, ANDREW;GILLIG, ANNABELLE