发明名称 |
BINDING PROTEINS TO INHIBITORS OF COAGULATION FACTORS |
摘要 |
The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use. |
申请公布号 |
US2014050743(A1) |
申请公布日期 |
2014.02.20 |
申请号 |
US201213980431 |
申请日期 |
2012.01.17 |
申请人 |
DITTMER FRANK;BUCHMUELLER ANJA;GERDES CHRISTOPH;TERSTEEGEN ADRIAN;GNOTH MARK JEAN;LINDEN LARS;HARRENGA AXEL;GRUDZINSKA-GOEBEL JOANNA;JESKE MARIO;SCHAEFER MARTINA;BIRKENFELD JOERG;PAULSEN HOLGER;FINNERN RICARDA;MAYER-BARTSCHMID ANKE;EICKER ANDREA;GREVEN SIMONE;STEINIG SUSANNE;BAYER INTELLECTUAL PROPERTY GMBH |
发明人 |
DITTMER FRANK;BUCHMUELLER ANJA;GERDES CHRISTOPH;TERSTEEGEN ADRIAN;GNOTH MARK JEAN;LINDEN LARS;HARRENGA AXEL;GRUDZINSKA-GOEBEL JOANNA;JESKE MARIO;SCHAEFER MARTINA;BIRKENFELD JOERG;PAULSEN HOLGER;FINNERN RICARDA;MAYER-BARTSCHMID ANKE;EICKER ANDREA;GREVEN SIMONE;STEINIG SUSANNE |
分类号 |
C07K16/44 |
主分类号 |
C07K16/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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