HMG1 ANTAGONIST FOR TREATING INFLAMMATORY SYMPTOMS

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist.SOLUTION: There is also disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk for sepsis or septic shock symptoms. There is further disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.