发明名称 |
Polyoma virus JC peptides and proteins in vaccination and diagnostic applications |
摘要 |
<p>The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable ofeliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immuno-compromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof.</p> |
申请公布号 |
AU2012288955(A1) |
申请公布日期 |
2014.02.20 |
申请号 |
AU20120288955 |
申请日期 |
2012.07.23 |
申请人 |
UNIVERSITAT ZURICH |
发明人 |
JELCIC, ILIJAS;MARTIN, ROLAND;SCHIPPLING, SVEN;SOSPEDRA, MIREIA;YOUSEF, SARA |
分类号 |
C07K14/025;A61K38/04;A61K38/16 |
主分类号 |
C07K14/025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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