Mycobacterial disease detection, treatment, and drug discovery

摘要

Methods for detecting and treating Mycobacterium-related diseases including reducing Mycobacterial virulence, reducing RV3133c dimerization, and treating a subject with a Mycobacterial infection using identified compounds are disclosed. Examples of 5 compounds useful in the treatment of Mycobacterium-related diseases include N-(4 [(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4 hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-lyl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2 hydroxyethyl)sulfonyl]phenyl } amino)acrylaldehyde. Further disclosed are methods for 10 identifying agents that interact with a polypeptide in a Mycobacterium cell. 48431911 (GHMattr) P78781.AU.1