发明名称 |
STAT3 INHIBITORS AND THEIR ANTICANCER USE |
摘要 |
<p>In one aspect, the invention relates to substituted substituted 6-amino-5,8-dioxo-5,8- dihydronaphthalene- 1 -sulfonamide analogs and derivatives thereof, substituted 4-amino-5H- naphtho[l,8-cd]isothiazol-5-one 1,1-dioxide analogs and derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.</p> |
申请公布号 |
WO2014028909(A1) |
申请公布日期 |
2014.02.20 |
申请号 |
WO2013US55474 |
申请日期 |
2013.08.16 |
申请人 |
OHIO STATE INNOVATION FOUNDATION;RESEARCH INSTITUTE OF NATIONWIDE CHILDREN'S HOSPITAL |
发明人 |
LI, CHENGLONG;YU, WENYING;LIN, JIAYUH |
分类号 |
A61K31/122;A61K31/136;A61K31/428;A61K31/429 |
主分类号 |
A61K31/122 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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