发明名称 Potent non-urea inhibitors of soluble epoxide hydrolase
摘要 The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
申请公布号 US8653273(B2) 申请公布日期 2014.02.18
申请号 US201113178117 申请日期 2011.07.07
申请人 RINDERSPACHER KIRSTEN ALISON;LANDRY DONALD W.;XIE YULI;LIU YIDONG;GONG GANGLI;DENG SHI-XIAN;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 发明人 RINDERSPACHER KIRSTEN ALISON;LANDRY DONALD W.;XIE YULI;LIU YIDONG;GONG GANGLI;DENG SHI-XIAN
分类号 C07D211/62 主分类号 C07D211/62
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