HLA ALLELES ASSOCIATED WITH ADVERSE DRUG REACTIONS AND METHODS FOR DETECTING SUCH

摘要

THIS INVENTION RELATES TO A METHOD OF DETERMINING THE PRESENCE OF CERTAIN HLA ALLELES, SUCH AS HLA-B* 1502 OR HLA-B*5801, AND A KIT FOR CARRYING OUT THIS METHOD. ALSO DISCLOSED IS A METHOD FOR ASSESSING WHETHER A PATIENT IS AT RISK FOR DEVELOPING ADVERSE DRUG REACTIONS (E.G., STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, OR HYPERSENSITIVITY SYNDROME) BASED ON THE PRESENCE OR ABSENCE OF A GENETIC MARKER (E.G., HLA-B* 1502, HLA-B*5801, OR HLA-B*46O1).