发明名称 |
ANTICANCER FUSION PROTEIN |
摘要 |
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity, preferably 85% identity and ending with the amino acid hTRAIL281; and domain (b) which is a sequence of an effector peptide inhibiting protein synthesis, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases. |
申请公布号 |
WO2013080147(A3) |
申请公布日期 |
2014.02.13 |
申请号 |
WO2012IB56806 |
申请日期 |
2012.11.28 |
申请人 |
ADAMED SP. Z O.O. |
发明人 |
PIECZYKOLAN, JERZY SZCZEPAN;PAWLAK, SEBASTIAN;SZYMANIK, MICHAL;PIECZYKOLAN, ANNA MARIA;ZEREK, BARTLOMIEJ MACIEJ;ROZGA, PIOTR;JAWORSKI, ALBERT ROBERT;TESKA-KAMINSKA, MALGORZATA IZABELA |
分类号 |
A61K38/00;C07K14/435;C07K14/52;C07K14/705;C07K19/00;C12N9/24 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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