PURIFIED PLASMODIUM AND VACCINE COMPOSITIONS

摘要

- 43 -PURIFIED PLASMODIUM AND VACCINE COMPOSITIONSDisclosed are substantially purifiedPlasmodiumsporozoites and preparations ofPlasmodiumsporozoites substantially separated from attendant non-sporozoitematerial, where the preparations ofPlasmodiumsporozoites have increasinglevels of purity. Vaccines and pharmaceutical compositions comprising purifiedPlasmodiumsporozoites are likewise provided. Methods of purifying preparationsofPlasmodiumsporozoites are also provided.[Figure 1a][Figure 1b]- 43 - PURIFIED PLASMODIUM AND VACCINE COMPOSITIONS Disclosed aresubstantially purified Plasmodium sporozoites and preparations of Plasmodiumsporozoites substantially separated from attendant non-sporozoite material,where the preparations of Plasmodium sporozoites have increasing levels ofpurity. Vaccines and pharmaceutical compositions comprising purifiedPlasmodium sporozoites are likewise provided. Methods of purifyingpreparations of Plasmodium sporozoites are also provided. [Figure I a] [Figure1 b]