发明名称 |
METHOD FOR PREPARING PRECURSOR USED FOR LABELING HEPATOCYTE RECEPTOR AND CONTAINING TRISACCHARIDE AND DTPA LIGAND |
摘要 |
A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, Nalpha,Nalpha-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure. |
申请公布号 |
US2014046045(A1) |
申请公布日期 |
2014.02.13 |
申请号 |
US201213571731 |
申请日期 |
2012.08.10 |
申请人 |
LIN CHIH-YUAN;CHANG YU;WANG JEN-TSUNG;HSU CHENG-FANG;KUO WEI-TI;YU HUNG-WEN;LIN WUU-JYH;WANG MEI-HUI;ATOMIC ENERGY COUNCIL - INSTITUTE OF NUCLEAR ENERGY RESEARCH |
发明人 |
LIN CHIH-YUAN;CHANG YU;WANG JEN-TSUNG;HSU CHENG-FANG;KUO WEI-TI;YU HUNG-WEN;LIN WUU-JYH;WANG MEI-HUI |
分类号 |
C07H15/04;C07H1/06 |
主分类号 |
C07H15/04 |
代理机构 |
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代理人 |
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地址 |
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