PROGNOSIS BIOMARKERS IN CARTILAGE DISORDERS

摘要

This application is directed to the use of biomarkers for prognosing disease severity in a subject having a cartilage disorder, such as osteoarthritis, cartilage injury, fractures affecting joint cartilage or surgical procedures with impact on joint cartilage (e.g. Microfracture). It also describes method of predicting sensitivity to a drug prior to drug administration in a subject having a cartilage disorder, as well as clinical management based on the likelihood of said patients of being non- sensitive, sensitive or highly sensitive to a drug treatment.