发明名称 |
N2,N4-BIS(4-(PIPERAZINE-1-YL)PHENYL)PIRIMIDINE-2,4-DIAMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER |
摘要 |
The present invention relates to a N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and to a composition containing same as an active ingredient for preventing or treating cancer. Since the compound according to the present invention has good effects in inhibiting the activities of anaplastic lymphoma kinase (ALK) and activated Cdc42-associated kinase (ACK1), the compound can have improved therapeutic effects against cancer cells having ALK fusion proteins such as EML4-ALK and NPM-ALK and is expected to be effective in preventing the recurrence of cancer. Therefore, the compound can be effectively used as a composition for preventing or treating cancer. |
申请公布号 |
WO2014025128(A1) |
申请公布日期 |
2014.02.13 |
申请号 |
WO2013KR04767 |
申请日期 |
2013.05.30 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
LEE, KWANGHO;KIM, HYOUNG RAE;PARK, CHI HOON;LEE, CHONG OCK;LEE, JONG KOOK;JUNG, HEE JUNG;CHO, SUNG YUN;CHAE, CHONG HAK;CHOI, SANG UN;HA, JAE DU |
分类号 |
C07D403/14;A61K31/506;A61P35/00;C07D403/12 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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