ANILIDES-ALKYLTHIOETHERS AS ACAT INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL DISEASES

摘要

The present invention relates to novel alkyl thioethers for the preparation of a medicament intended to prevent or to treat a disorder due to a dysfunction of the sebaceous glands in humans or animals. The compounds according to the present invention exert a strong inhibition of acyl CoA: cholesterol O-acyl transferase (ACAT): (I) in which - R1 represents a hydroxyl or amino group, - R2 represents a hydrogen or a methyl radical, - A represents a group chosen from: (II) - n represents an integer from 5 to 13.