发明名称 Ethynyl nitrogen containing heteroaryl pyrazolidin-3-one derivatives
摘要 The present invention relates to ethynyl derivatives of formula I wherein G, X, R1, R2, R3, R3', R4, and R4' are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5).
申请公布号 US8648088(B2) 申请公布日期 2014.02.11
申请号 US201213454167 申请日期 2012.04.24
申请人 JAESCHKE GEORG;JOLIDON SYNESE;LINDEMANN LOTHAR;RICCI ANTONIO;RUEHER DANIEL;STADLER HEINZ;VIEIRA ERIC;HOFFMANN-LA ROCHE INC. 发明人 JAESCHKE GEORG;JOLIDON SYNESE;LINDEMANN LOTHAR;RICCI ANTONIO;RUEHER DANIEL;STADLER HEINZ;VIEIRA ERIC
分类号 C07D401/04;A61K31/4439;A61K31/506;C07D403/04 主分类号 C07D401/04
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