发明名称 |
Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers |
摘要 |
Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, antibodies specific for hyaluronan receptors, hyaluronan mimetics, inhibitors of hyaluronan synthesis, and stimulators of hyaluronan degradation. |
申请公布号 |
US8648047(B2) |
申请公布日期 |
2014.02.11 |
申请号 |
US201113338809 |
申请日期 |
2011.12.28 |
申请人 |
TOOLE BRYAN P.;MISRA SUNITI;GHATAK SHIBNATH;TUFTS UNIVERSITY |
发明人 |
TOOLE BRYAN P.;MISRA SUNITI;GHATAK SHIBNATH |
分类号 |
A01N61/00;A61K31/00;A61K31/17;A61K31/337;A61K31/475;A61K31/519;A61K31/704;A61K31/726;A61K31/728;A61K38/00;A61K38/13;A61K45/00;A61K45/06;A61P31/04;A61P35/00;A61P35/02;A61P43/00;C12Q1/02;G01N33/15;G01N33/50 |
主分类号 |
A01N61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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