| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: pharmaceutical composition contains 11-deoxy-prostaglandine compound and fatty acid ester prepared of fatty acid having C6-C24 carbon atoms, and monobasic C1-C6 alcohol. The 11-deoxy-prostaglandine compound may be stabilised by mixing it with the above fatty acid ester. Preferentially, the 11-deoxy-prostaglandine compound represents the type E11-deoxy-13,14-dihydro-15-keto-16,16-difluoro-prostaglandine compound; the above fatty acid ester is preferentially isopropyl palmitate. What is also described is a preparation in the form of a soft gelatin capsule that comprises a soft gelatin capsule shell containing polyol and/or sugar alcohol as a softening agent, and a pharmaceutical composition containing the 11-deoxy-prostaglandine compound and the fatty acid ester (as an excipient), wherein the above composition is encapsulated into the gelatin capsule shell.EFFECT: invention provides stabilising the 11-deoxy-prostaglandine compound.31 cl, 4 tbl, 2 ex |
