发明名称 |
N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range for use in pharmaceutical formulations. |
摘要 |
<p>The present invention relates to the crystalline mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide in a definite particle size distribution and a specific surface area range, which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions, as well as to pharmaceutical compositions containing said N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate having the afore-mentioned particle size distribution and specific surface area range.</p> |
申请公布号 |
AU2012314473(A1) |
申请公布日期 |
2014.02.06 |
申请号 |
AU20120314473 |
申请日期 |
2012.09.26 |
申请人 |
AICURIS GMBH & CO. KG |
发明人 |
SCHWAB, WILFRIED;BIRKMANN, ALEXANDER;PAULUS, KERSTIN;VOGTLI, KURT;HAAG, DIETER;MAAS, STEPHAN;RUEPP, KRISTIAN |
分类号 |
C07D417/12;A61K31/4402;A61P31/00;A61P31/22 |
主分类号 |
C07D417/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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