| 摘要 |
The present invention relates to the field of obesity. More specifically, the present invention provides methods and compositions useful in treating obesity and obesity-associated conditions. In a specific embodiment, a method for treating obesity comprises administering an effective amount of an agent that inhib its expression of neuropeptide Y (NPY). In another embodiment, the present invention provides a recombinant nucleic acid construct comprising a nucleic acid sequence encoding an oligonucleic acid, wherein the oligonucleic acid comprises at least one sequence substantially complementary to at least a part of the neuropeptide Y (NPY) gene or transcript thereof, and wherein the oligonucleic acid inhibits or reduces the expression of NPY. |
