发明名称 |
Taste masked pharmaceutical composition |
摘要 |
This application relates to taste masked multi-layered particles comprising a pharmaceutically active ingredient, comprising: (a) an inert core, (b) one or more coating layer(s) comprising the pharmaceutically active ingredient and a binder, (c) an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound, comprising a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG or (ii) PVP and (d) an outer coating layer (final or taste masking coating) free from a low molecular weight water- soluble ionic compound comprising (i) a poly(meth)acrylate or (ii) a mixture comprising 60-90% (w/w) EC and 10-40% (w/w) HPMC, wherein the pharmaceutically active ingredient is water- soluble and comprises either at least one basic group and/or a bitter taste. Further disclosed are methods for the production of such particles and pharmaceutical compositions comprising them. |
申请公布号 |
AU2012296925(A1) |
申请公布日期 |
2014.02.06 |
申请号 |
AU20120296925 |
申请日期 |
2012.08.10 |
申请人 |
BOEHRINGER INGELHEIM VETMEDICA GMBH |
发明人 |
FOLGER, MARTIN;LEHNER, STEFAN;GRAVE, ANNETTE;POELLINGER, NORBERT;SEIDLER, RANDOLPH |
分类号 |
A61K9/00;A61K9/50;A61K31/55 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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