COMPOSITION COMPRISING REBAMIPIDE AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING HYPERLIPEMIA AND DISEASES ASSOCIATED THEREWITH

摘要

The present invention relates to a pharmaceutical use of rebamipide to be used in preventing or treating hyperlipemia and diseases associated therewith, and more particularly, to a composition comprising rebamipide as an active ingredient for preventing or treating hyperlipemia and diseases associated therewith. The rebamipide compound according to the present invention may: inhibit the generation of TNF-a, IL-6 and IL-1b which are hyperlipemia-inducing inflammatory cytokines secreted by macrophage; inhibit the generation of foam cells which form artherosclerotic plaque precursor cells; lower the levels of total cholesterol, LDL-cholesterol and neutral fat to improve blood lipid; improve fatty liver; inhibit an activity of B cells; and decrease the expression of Th17 for accelerating the generation of artherosclerotic plaque and increase the expression of Treg cells for controlling an inflammatory reaction. Accordingly, the rebamipide compound can be valuably used as a pharmaceutical composition for preventing or treating hyperlipemia and diseases associated therewith such as arteriosclerosis, heart failure and hypertensive heart disease through the above-described various mechanisms. Furthermore, the rebamipide compound is free from toxicity or side effects for a drug, and can therefore be used with an easy mind even over a long period of time, and has an effect of in-vivo stability.