发明名称 |
CHIRAL 3-HYDROXYPYRID-4-ONE DERIVATIVE, AND SYNTHESIS AND USE THEREOF |
摘要 |
<p>Disclosed are a chiral 3-hydroxypyrid-4-one derivative and a salt thereof. The compound is acquired by reacting methyl maltol or ethyl maltol with benzyl chloride to acquire a 3-benzyl protected maltol, then by reacting compound VII with different chiral amino alcohols to acquire 3-benzyloxypyrid-4-one, and finally by performing a palladium on carbon-catalyzed hydride reduction deprotection on compound IX. The compound of the present invention is capable of having iron ion chelating bioactivity, and is applicable in preparing an anti-iron overload medicament. The structure of the compound of the present invention is represented as formula ( I ).</p> |
申请公布号 |
EP2692724(A1) |
申请公布日期 |
2014.02.05 |
申请号 |
EP20110862562 |
申请日期 |
2011.12.22 |
申请人 |
ZHEJIANG UNIVERSITY |
发明人 |
HIDER, ROBERT;LIU, ZUDONG;YU, YONGPING;LI, ZHI |
分类号 |
C07D309/40;A61K31/351;A61P7/06;A61P25/00;A61P25/28;A61P35/00;A61P39/04 |
主分类号 |
C07D309/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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