发明名称 |
Encochleation methods, cochleates and methods of use |
摘要 |
Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed. |
申请公布号 |
US8642073(B2) |
申请公布日期 |
2014.02.04 |
申请号 |
US20070653434 |
申请日期 |
2007.01.11 |
申请人 |
MANNINO RAPHAEL J.;GOULD-FOGERITE SUSAN;KRAUSE-ELSMORE SARA L.;DELMARRE DAVID;LU RUYING;BIODELIVERY SCIENCES INTERNATIONAL, INC.;UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
MANNINO RAPHAEL J.;GOULD-FOGERITE SUSAN;KRAUSE-ELSMORE SARA L.;DELMARRE DAVID;LU RUYING |
分类号 |
A61K9/127;A61K31/00;A61K31/7048 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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