| 发明名称 |
Human antibodies that bind human tnfa |
| 摘要 |
NZ 598487 Disclosed is a method for inhibiting human TNFαactivity in vitro comprising contacting human TNFαwith an antibody such that human TNFαactivity is inhibited, wherein the antibody is an isolated human antibody, or an antigen-binding portion thereof, that dissociates from human TNFαwith a Kd of 1 x 10-8 M or less and a Koff rate constant of 1 x 10-3 s-1 or less, both determined by surface plasmon resonance, and neutralises human TNFαcytotoxicity in a standard in vitro L929 assay with an IC50 of 1 x 10-7 M or less. |
| 申请公布号 |
NZ598487(A) |
申请公布日期 |
2014.01.31 |
| 申请号 |
NZ19970598487 |
申请日期 |
1997.02.10 |
| 申请人 |
ABBVIE BIOTECHNOLOGY LTD |
发明人 |
SALFELD JOCHEN G;ALLEN DEBORAH J;KAYMAKCALAN ZEHRA;LABKOVSKY BORIS;MANKOVICH JOHN A;MCGUINESS BRIAN T;ROBERTS ANDREW J;SAKORAFAS PAUL;HOOGENBOOM HENDRICUS R J M;SCHOENHAUT DAVID;VAUGHAN TRISTAN J;WHITE MICHAEL;WILTON ALISON J |
| 分类号 |
C12N15/09;C12N15/13;A61K31/00;A61K31/40;A61K31/403;A61K31/404;A61K31/415;A61K31/4164;A61K31/4178;A61K31/505;A61K31/517;A61K31/52;A61K31/529;A61K31/57;A61K31/573;A61K31/675;A61K38/00;A61K38/04;A61K38/16;A61K39/39;A61K39/395;A61P1/00;A61P1/04;A61P1/16;A61P3/10;A61P7/00;A61P7/04;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P11/16;A61P13/12;A61P17/00;A61P17/02;A61P19/02;A61P19/06;A61P25/00;A61P27/02;A61P29/02;A61P31/00;A61P31/04;A61P31/12;A61P31/18;A61P33/06;A61P35/00;A61P35/04;A61P37/00;A61P37/02;A61P37/06;A61P37/08;A61P39/02;C07K16/24;C12N1/21;C12N5/10;C12N15/28;C12N15/64;C12P21/08;G01N33/53;G01N33/543;G01N33/564;G01N33/576;G01N33/68 |
主分类号 |
C12N15/09 |
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