发明名称 |
Switch costimulatory receptors |
摘要 |
The present invention relates generally to a fusion protein that when displayed on a cell can convert a negative signal into a positive signal in the cell. The fusion protein is a chimeric protein in that the protein comprises at least two domains, wherein the first domain is a polypeptide that is associated with a negative signal and the second domain is a polypeptide that is associated with a positive signal. Thus, the invention encompasses switch receptors that are able to switch negative signals to positive signals for enhancement of an immune response. |
申请公布号 |
AU2012290342(A1) |
申请公布日期 |
2014.01.30 |
申请号 |
AU20120290342 |
申请日期 |
2012.07.27 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
JUNE, CARL H.;ZHAO, YANGBING |
分类号 |
A61K48/00;A61K38/17 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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