Methods for effective remyelination in patients are disclosed comprising treating the patient with an androgen receptor ligand which exerts binding to androgen receptors and elicits androgen-receptor-induced biological responses at a dosage sufficient to induce remyelination. The androgen compound preferably comprises MENT in an androgen targeting both androgen and estrogen receptors, and the methods include combining the androgen compound with a progestin compound in order to provide both contraception in men and treatment for neurodegeneration.
申请公布号
EP2688571(A1)
申请公布日期
2014.01.29
申请号
EP20120712490
申请日期
2012.03.22
申请人
THE POPULATION COUNCIL, INC.
发明人
SITRUK-WARE, REGINE;SCHUMACHER, MICHAEL MARIA HELMUT;GHOUMARI, ABDELMOUMAN;GHANDOUR, SAID;HUSSAIN, RASHAD;BIELECKI, BARTOSZ