发明名称 |
Treatment method for epithelial cancerous organism |
摘要 |
It is an object of the present invention to provide a novel method for decreasing the number of clinical cases for which trastuzumab administration is ineffective. The present invention provides a method for treating a living individual with epithelial cancer comprising: step (a) of selectively reducing KLRG1-positive immunocytes in the peripheral blood of a living individual with epithelial cancer ex vivo, which is positive for a cancer-specific membrane antigen expressed in epithelial cancer cells and positive for a KLRG1 ligand; and step (b) of administering, to the living individual, a therapeutic agent for cancer comprising an antibody reacting with the cancer-specific membrane antigen expressed in epithelial cancer cells and having antibody-dependent cell cytotoxicity. |
申请公布号 |
US8637084(B2) |
申请公布日期 |
2014.01.28 |
申请号 |
US20100835010 |
申请日期 |
2010.07.13 |
申请人 |
YASUTAKE MIKITOMO;NINOMIYA KASUMI;HONDA JUNICHI;OCHIAI ATSUSHI;YAMAUCHI CHISAKO;ASAHI KASEI MEDICAL CO., LTD.;NATIONAL CANCER CENTER |
发明人 |
YASUTAKE MIKITOMO;NINOMIYA KASUMI;HONDA JUNICHI;OCHIAI ATSUSHI;YAMAUCHI CHISAKO |
分类号 |
A61K35/28;A01N25/00 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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