TRANSPORT MOLECULES USING REVERSE SEQUENCE HIV-TAT POLYPEPTIDES

摘要

PROBLEM TO BE SOLVED: To provide novel transport molecules that are capable of increasing the transmembrane or intracellular penetration of cargo molecules.SOLUTION: This invention relates to novel transport molecules that comprise a polypeptide having amino acid residues arranged in a sequence that is the reverse-sequence of the basic portion of the HIV-TAT protein. The novel transport polypeptides are useful for transmembrane or intracellular delivery of cargo molecules, non-limiting examples of which include polypeptides and nucleic acids. The novel transport polypeptides may be covalently or non-covalently bound to the cargo molecules.