SUBSTITUTED IMIDAZOLE DERIVATIVE HAVING AGONIST-LIKE ACTIVITY AT α2B OR 2B/2C ADRENERGIC RECEPTOR

摘要

PROBLEM TO BE SOLVED: To treat muscle spasticity including hyperactive micturition, diarrhea, diuresis, withdrawal syndromes, pain including neuropathic pain, neurodegenerative diseases, memory and cognition deficits, psychoses including manic disorders and anxiety, hypertension, cardiac ischemia, congestive heart failure, and nasal congestion without sedating or cardiovascular side effects.SOLUTION: Compounds having selective agonist activities for one or both of the α2B and α2C adrenoceptor receptor subtypes in preference to the α2A adrenoceptor receptor subtype, are used as therapeutic agents. The compounds are represented by the formula I and selected from compound group defined in the specifications.