发明名称 |
Method of inhibiting apolipoprotein-E expression comprising administering a triarylmethyl amine compound |
摘要 |
This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: wherein the R1 group may comprise acyclic amines and aliphatic amines. The R2 group may comprise one of three aryl varieties: aryl, substituted aryl, or heterocycle. Triarylamine compounds inhibit apolipoprotein E expression in mammalian cells. In one aspect of the invention the mammalian cells may be human cells, and more specifically may be human brain cells. |
申请公布号 |
US8633195(B1) |
申请公布日期 |
2014.01.21 |
申请号 |
US201213536738 |
申请日期 |
2012.06.28 |
申请人 |
MAITRA SANTANU;PATEL NILAY;FRESNO CALIFORNIA STATE UNIVERSITY;FULLERTON CALIFORNIA STATE UNIVERSITY |
发明人 |
MAITRA SANTANU;PATEL NILAY |
分类号 |
A61K31/495;A61K31/40;A61K31/445 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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