发明名称 |
METHOD FOR SUPPRESSING COLORING OF ADHESIVE PREPARATION CONTAINING DONEPEZIL AND METHOD FOR REDUCING AMOUNTS OF DONEPEZIL-RELATED SUBSTANCES FORMED |
摘要 |
<p>[PROBLEMS] To prevent the coloration in a donepezil-containing skin adhesive preparation to achieve the appearance having a natural color, or the like. [MEANS FOR SOLVING PROBLEMS] Disclosed is a method for preventing the coloration in a skin adhesive preparation comprising a substrate and an adhesive layer, wherein the adhesive layer comprises an adhesive agent and donepezil. The method is characterized by adding ascorbic acid or a metal salt or ester thereof and a metabisulfite metal salt to the adhesive layer. Preferably, the method comprises the steps of: providing a preparation product comprising the adhesive agent, donepezil, ascorbic acid or a metal salt or ester thereof and a metabisulfite metal salt; and applying the preparation product onto the surface of the substrate to form the adhesive layer.</p> |
申请公布号 |
CA2671000(C) |
申请公布日期 |
2014.01.21 |
申请号 |
CA20072671000 |
申请日期 |
2007.11.30 |
申请人 |
NITTO DENKO CORPORATION;EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
NISHI, SUMIYO;HANATANI, AKINORI;SEKIYA, JUNICHI;TERASHI, SACHIKO;AKEMI, HITOSHI;WASHIRO, SATOKO |
分类号 |
A61K31/445;A61K9/70;A61K47/02;A61K47/22;A61P25/28 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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