| 摘要 |
PROBLEM TO BE SOLVED: To provide a producing method of high purity of mitiglinide calcium hydrate efficiently by suppressing formation of poor solubility impurities in the hydrolysis method of (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate ester by using a hydroxide of alkali metal.SOLUTION: Mitiglinide calcium hydrate is produced by a chlorination reaction of calcium after adjusting pH of fluid of a reaction solution obtained by reacting hydroxide of alkali metal and (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate ester in a range of weakly acidic to weakly alkaline. |
