THE ED-A ANTIGEN OF FIBRINOGEN IS ASSOCIATED WITH THE NEOVASCULATURE OF TUMOUR METASTASES

摘要

The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases. Figure 1 A4 Terminal perfusion and biolinyladion of prclelns B3 + accessible 1vor Vie blood swrsail Liver from liedilby mice [-9 Vverraerlo'. lIVER r F~w 13LOOD VIESSEL 4Protein extraction j). .~~* ~t'' 4 streplavidln rs- :0 V 4 On-resin tryplc digestion 4- . ______ K~~sBIDil t ie Peptiide analysis by nano-HPLO and MALDI TOFITOFiK' t~V hrf