发明名称 |
HUMAN MONOCLONAL ANTIBODIES TO ACTIVIN RECEPTOR-LIKE KINASE-1 |
摘要 |
<p>The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclosure also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The disclosure also relates to transgenic animals or plants comprising nucleic acid molecules of the present disclosure.</p> |
申请公布号 |
KR20140004261(A) |
申请公布日期 |
2014.01.10 |
申请号 |
KR20137033726 |
申请日期 |
2006.09.06 |
申请人 |
AMGEN FREMONT INC.;PFIZER INC. |
发明人 |
NORTH MICHAEL AIDAN;AMUNDSON KARIN KRISTINA;BEDIAN VAHE;BELOUSKI SHELLEY SIMS;HU LOWE DANA DAN;JIANG XIN;KARLICEK SHANNON MARIE;KELLERMANN SIRID AIMEE;THOMSON JAMES ARTHUR;WANG JIANYING;WICKMAN GRANT RAYMOND;ZHANG JINGCHUAN |
分类号 |
C07K16/40;A61K39/395;A61P35/00;C12N15/13 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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