PHARMACEUTICAL COMPOSITION AND DIAGNOSIS METHOD FOR INFLAMMATORY SKIN DISEASE, DISORDER OR SYMPTOM

摘要

PROBLEM TO BE SOLVED: To provide a treatment method of a skin inflammatory disease, disorder or symptom.SOLUTION: Treatment or prevention of an inflammatory skin disease, disorder or symptom is carried out by modulating a protein normally controlled by caspase-8 in the skin or by increasing the activity or level of caspase-8 in the skin, where a medicament selected from (i) caspase-8 or its fragment, (ii) a polynucleotide encoding caspase-8 or its fragment and (iii) an expression vector comprising the polynucleotide of (ii) is locally administered.