发明名称 |
METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS |
摘要 |
The invention provides an in vitro method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells. The method comprises contacting an isolated somatic cell being reprogrammed into an iPS cell with an inhibitor of p53 function. The invention also provides an in vitro method of producing iPS cells. The method comprises bringing (a) nuclear reprogramming substances or nucleic acids encoding the nuclear reprogramming substances and (b) an inhibitor of p53 function into contact with a somatic cell. |
申请公布号 |
US2014011279(A1) |
申请公布日期 |
2014.01.09 |
申请号 |
US201313942208 |
申请日期 |
2013.07.15 |
申请人 |
KYOTO UNIVERSITY |
发明人 |
YAMANAKA SHINYA;TAKAHASHI KAZUTOSHI;OKITA KEISUKE |
分类号 |
C12N5/074;C12N15/85 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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