MODIFIED PAYLOAD MOLECULES AND THEIR INTERACTIONS AND USES

摘要

An object of the present invention relates to a composition comprising a payload molecule such as a small interfering nucleic acid (siNA) and albumin or fragments thereof, or fusion polypeptides comprising variant albumin or fragments thereof, of a parent albumin. Another object of the present invention relates to a payload molecule such as a siNA conjugated with one or more cholesteryl and/or one or more fatty acid. A further object of the present invention relates to a payload molecule such as a siNA the composition of the present invention for use as a medicament. Yet another object of the present invention relates topayload molecule such as asiNA or the composition of the present invention for use as in regulating a genetic expression of a transcript or protein associated with a disease.