发明名称 |
ORGANIC COMPOSITIONS TO TREAT KRAS-RELATED DISEASES |
摘要 |
The present disclosure relates to RNAi agents useful in methods of treating KRAS-related diseases such as a proliferative disease, including without limitation a solid or liquid cancer, adenocarcinoma, colorectal cancer, advanced and/or metastatic colorectal cancer, colon cancer, lung, non-small cell lung cancer and lung adenocarcinoma, acute myelogenous lung, bladder, brain, breast, cervical, endometrial, gastric, head and neck, kidney, leukemia, myelodysplastic syndrome, myeloid leukemia, liver, melanoma, ovarian, pancreatic, prostate, testicular, thyroid cancers, and cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to KRAS. |
申请公布号 |
WO2013166004(A3) |
申请公布日期 |
2014.01.03 |
申请号 |
WO2013US38847 |
申请日期 |
2013.04.30 |
申请人 |
NOVARTIS AG;BETTENCOURT, BRIAN;MILSTEIN, STUART;TOUDJARSKA, IVANKA;MCDONALD, EARL;SCHLABACH , MICHAEL JR.;STEGMEIER, FRANK P.;WARMUTH, MARKUS;GAMPA, KALYANI;HUESKEN, DIETER;STUMP, MARK;WEILER, JAN;JAGANI, ZAINAB |
发明人 |
BETTENCOURT, BRIAN;MILSTEIN, STUART;TOUDJARSKA, IVANKA;MCDONALD, EARL;SCHLABACH , MICHAEL JR.;STEGMEIER, FRANK P.;WARMUTH, MARKUS;GAMPA, KALYANI;HUESKEN, DIETER;STUMP, MARK;WEILER, JAN;JAGANI, ZAINAB |
分类号 |
C12N15/113;A61K31/713;A61P35/00 |
主分类号 |
C12N15/113 |
代理机构 |
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