发明名称 |
SEROLOGIC CORRELATES OF PROTECTION AGAINST BACILLIS ANTHRACIS INFECTION |
摘要 |
Regions of B. anthracis protective antigen are provided representing sequences recognized by antibodies in subjects that have vaccine induced lethal toxin neutralizing anti-PA IgG responses. The recognition of these PA regions enhances the utility of anti-PA IgG reactivity as an immune correlate of protection against anthrax in a subject and increases predictive probability of survival. Also provided are vaccines that include at least one of these PA regions that when administered to a subject improve the predictive value of vaccine induced anti-PA IgG and TNA responses as immune correlates of protection against inhalation anthrax. |
申请公布号 |
US2014004139(A1) |
申请公布日期 |
2014.01.02 |
申请号 |
US201314010668 |
申请日期 |
2013.08.27 |
申请人 |
CENTERS FOR DISEASE CONTROL AND PREVENTION |
发明人 |
SEMENOVA VERA A.;QUINN CONRAD P.;POHL JAN;SVOBODA PAVEL;DALTON SHANNON;SCHIFFER JARAD M. |
分类号 |
C07K14/32 |
主分类号 |
C07K14/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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