摘要 |
PURPOSE: A liquid phase hard capsule containing naproxen liquid is provided to ensure long-term stability. CONSTITUTION: A hard capsule contains a liquid phase composition containing naproxen, 5-70 wt% of alkandiol, surfactant, base, and water. The alkandiol is diethylene glycol monoethyl ether. The composition additionally contains 1.5-70 wt% of polyethylene glycol. The viscosity of the liquid phase composition is 300-20,000 cps. The surfactant is 0.03-30 wt% of polysorbate. The bas and water are contained in 1-20 wt% and 0.01-15 wt%. |