发明名称 |
Use of a latent myostatin complex comprising a myostatin pro-peptide and a myostatin c-terminal fragment and a metalloprotease for the preparation of a pharmaceutical composition for modulating myostatin activation |
摘要 |
<p>The invention provides an in vitro method of decreasing myostatin activation. The method comprises contacting a sample comprising a latent myostatin complex comprising a myostatin pro peptide and a myostatin C-terminal fragment, and a metalloprotease that can cleave the myostatin pro peptide, with an agent that decreases proteolytic cleavage of the pro peptide by the metalloprotease, thereby decreasing myostatin activation. The metalloprotease is a bone morphogenic protein-1/tolloid (BMP-1/TLD) family member and the agent is a peptide selected from the group consisting of SEQ ID NOS: 9-23. Also provided is such an agent for use in decreasing myostatin activation in a subj ect.</p> |
申请公布号 |
IL166651(A) |
申请公布日期 |
2013.12.31 |
申请号 |
IL20050166651 |
申请日期 |
2005.02.02 |
申请人 |
WYETH LLC;WISCONSIN ALUMNI RESEARCH FOUNDATION;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
|
分类号 |
A61K;A61K38/00;A61K38/16;A61K38/18;C07K;C07K14/475;C12N;C12N9/64;C12Q |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|