NEW METHODS FOR THE PREPARATION OF TAXANES USING CHIRAL AUXILIARIES

摘要

The present invention relates to a stereoselective synthesis of novel .beta.-lactam dimers as useful precursors for the preparation of paclitaxel, docetaxel, and analogues thereof. More particularly, the new .beta.-lactams are prepared from readily available and enantiomerically pure chiral auxiliaries. The .beta.-lactams are then reacted with a suitably protected taxane to produce diastereomerically enriched side chain-bearing taxanes. Finally, the chiral auxiliary is cleaved and protecting groups are removed to provide the desired taxane.